Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion
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Stressful preconditioning and HSP70 overexpression attenuate proteotoxicity of cellular ATP depletion.
Rat H9c2 myoblasts were preconditioned by heat or metabolic stress followed by recovery under normal conditions. Cells were then subjected to severe ATP depletion, and stress-associated proteotoxicity was assessed on 1) the increase in a Triton X-100-insoluble component of total cellular protein and 2) the rate of inactivation and insolubilization of transfected luciferase with cytoplasmic or n...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2002
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00503.2001